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Evidence building for possible virus link in T1D development

A new study suggests a link between enteroviruses, and the development of type 1 diabetes (T1D). This study, part-funded by JDRF, isn’t the first to find this link but the authors say it’s the largest and most definitive study of its kind to date.

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Professor Keikki HyÖty and Dr Hanna Honkanen led this study published in Diabetologia at the University of Tampere in Finland. They found that children at high risk of T1D who then go on to develop the disease, had a higher number of enterovirus infections compared to those without the disease.

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World leading experts discuss innovative ideas in T1D research

In early December, the Type 1 Diabetes Clinical Research Network (T1DCRN) brought together leading national and international experts in type 1 diabetes (T1D) to the Woolcock Institute in Sydney for the 2016 BRIdGE Symposium.

T1DCRN 2016 Symposium
Prof Chantal Mathieu, Director of the Endocrinology Clinic at the University Hospital of Leuven

This year’s theme was innovation in autoimmunity and complications. A mix of high calibre clinicians, clinical researchers and basic researchers from areas such as immunology, genetics and paediatrics mingled and shared their novel ideas for accelerating research in T1D.

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The need to screen for additional autoimmune diseases

People with type 1 diabetes (T1D) often develop other autoimmune diseases, but the frequency and predictive factors for development have not been characterised.

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While the mechanisms for T1D are still under investigation, it is thought there are common immune system pathways that may be similar across more than one, or all autoimmune diseases.  Read More

Carb counting: Could there be a better way?

The current gold standard for calculating mealtime insulin in people with type 1 diabetes is carbohydrate counting using the carbohydrate to insulin ratio – the amount of insulin that will cover a certain amount of carbohydrates. Recent research and clinical observations from continuous glucose monitoring (CGM) data has seen that people can experience delayed high blood glucose levels (hyperglycaemia) hours after eating a meal high in fat and/or protein.  Read More

Australian diabetes expert recognised with prestigious international award

JDRF-funded researcher Professor Mark Cooper, Chief Scientific Officer and Head of the Diabetes Division at Baker IDI Heart and Diabetes Research Institute, has become the first Australian to receive the prestigious Claude Bernard award from the European Association for the Study of Diabetes this month.  Read More

T1DCRN awards nearly $4 million in new funding for the next generation of type 1 diabetes research

Minister Simon Birmingham has announced that nearly $4 million has been awarded to Australian researchers for the Type 1 Diabetes Clinical Research Network (T1DCRN) Australasian Diabetes Data Network (ADDN) and Career Development Awards.

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Common virus increases activity of T1D-risk genes in pancreatic islets

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Image credit: University of Pennsylvania

Infection with a common virus known as coxsackievirus B has long been thought to be associated with the development of type 1 diabetes. Now, researchers have published evidence that this virus could be driving the activity of the very genes that increase the risk of developing type 1 diabetes.  Read More

Early probiotic use could help prevent type 1 diabetes in at-risk children

Giving probiotics to babies in the first few weeks of life may lower their risk of developing type 1 diabetes, a recent study has found.

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The study, published in JAMA Pediatrics found that children who were given probiotics within the first 27 days of life had a 60% reduction in the risk of developing islet autoimmunity, compared with children who were first given probiotics after 27 days or not at all. Read More

Sanofi and Lexicon Pharmaceuticals partner on new non-insulin therapy for type 1 diabetes

JDRF partner Sanofi and Lexicon Pharmaceuticals have announced a new collaboration to develop and commercialise a new oral drug for the treatment of type 1 diabetes.

Nadav Kidron, CEO of Oramed Pharmaceuticals, poses for a photo in Jerusalem

The drug is called sotagliflozin and is used in conjunction with insulin to help improve blood glucose levels by blocking glucose absorption in the kidneys and the gut.  Read More

World first trial to slow type 1 diabetes development in children

The Australian Type 1 Diabetes Clinical Research Network has partnered with the Immune Tolerance Network to launch a new Australian clinical trial to slow the development of newly diagnosed type 1 diabetes in children.

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The EXTEND-P trial is expected to begin recruitment in March 2016 to test the ability of an existing drug called tocilizumab to preserve beta cell function. Tocilizumab, sold under the brand name Actemra, is currently approved for use in children with juvenile arthritis. Read More